Abul Kalam Azad1,Wan Mohd Azizi Wan Sulaiman2, Ismail N. Z3, Shyam Sundor Shaha4, Nushrat Khan Sunzida5
1-3Department of Basic Medical Sciences, Faculty of Pharmacy, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmad Shah, 25200 InderaMahkota, Kuantan, Pahang, Malaysia.
4-5Department of Biochemistry, Gonoshasthaya Samaj Vittik Medical College, Gono University, Dhaka-1344, Bangladesh.
Md. Abul Kalam Azad,
Department of Basic Medical Sciences,
Faculty of Pharmacy, International Islamic University Malaysia,
Jalan Sultan Ahmad Shah, 25200 Kuantan, Pahang, Malaysia.
Tel: 5704871, Fax: 5706775, Mobile No: +8801755977783
Objective: This particular study aims to investigate the effect of mineral oil in different products on the barrier function of normal skin, as measured by transepidermal water loss (TEWL) and hydration. Methods: In this study, 15 female volunteers were divided into three groups, which corresponded with three different brands of moisturizers. The volunteers were treated with one test preparation on one volar forearm twice daily for 3 weeks, while leaving the other forearm untreated to serve as the control. After 3 weeks, both volar forearms, treated and control, were assessed for the measurement of TEWL and hydration by using DermaLab® Combo, and the readings were compared to the baseline. Results: Changes were observed after 3 weeks treatment of mineral oil-based moisturizers, in which both TEWL and hydration increased for both control and test sides, but the percentage of increment was lower than that observed with test side. Moisturizers influence the skin barrier function of normal skin, as measured by TEWL and hydration. TEWL readings of all subjects for all the three types of products increased significantly from the baseline. Conclusions: This results shows that the side treated with mineral-oil based moisturizers were able to promote greater degree of skin hydration compared to the untreated side.
Keywords: DermaLab®, Dehydration, Moisturizer, Trans Epidermal Water Loss