Research Articles

2020  |  Vol: 6(6)  |  Issue: In Press  |  https://doi.org/10.31024/ajpp.2020.6.6.3
Hepatoprotective activity of Pentatropis nivalis against Carbon tetrachloride induced hepatic damage in rats

Nilesh P. Babre1*, T. Shivaraj Gouda2, Narayanswamy Lachmanan Gowrishankar3

1Department of Pharmacology, VIVA Institute of Pharmacy, Virar (E), Palghar, Mumbai, 401303 India

2Department of Pharmacology, NET Pharmacy College, Raichur - 584103, Karnataka, India

3Department of Pharmacognosy, Prime College of Pharmacy, Erattayal, Kodumbu, Palakkad - 678551, Kerala, India

*Address for Corresponding Author

Nilesh P. Babre

Late Shri Vishnu Waman Thakur charitable Trust`s

VIVA Institute of Pharmacy, At. Shirgaon, Veer Sawarkar Road, Virar (E)

Taluka: Vasai, Dist. Palghar, Mumbai, Maharashtra, India


Abstract

Objective: To study the hepato protective activity of aerial parts of Pentatropis navalis in CCL4 induced rats.  Material and methods: Hepatotoxicity was induced by CCL4 (2 ml/kg i. p) in rats. Silymarin was used as a standard drug and Methanol extract of Pentatropis nivalis 200 mg and 400 mg /kg b. wt.  were taken for the study. The degree of protection was determine biochemical parameter like SGOT, SGPT, ALP, Cholesterol, Total Bilirubin and Total Protein level in blood serum. Results and Conclusion: The present study revealed that the methanol extract of aerial part of Pentatropis nivalis contained alkaloids, cardiac glycosides, flavonoids, glycosides, phenols, resins, saponins, tannins, steroids and terpenoids. A significant increase in serum SGPT, SGOT and ALP ,Cholesterol, total bilirubin and marked decrease in  total protein level was observed in the animals treated with CCL4 (2 ml/kg i. p. ) as compared to normal. Treatment with MEPN (200mg/kg b. wt.) and (400mg/kg b. wt.) for the five days decrease the all the above parameter significantly (P<0.001) Silymarin pretreatment produces significantly (P <0.001) decreases all the parameter when compared with positive control group. The MEPN at the dose of 400 mg/kg b. wt. exhibited significant activity as compared to MEPN at the dose of 200 mg/kg b. wt. Histopathological study also marked that the improvement in hepatocytes is dose dependent manner. Further study need to isolation and characterization of bioactive molecules in the Pentatropis nivalis.  

Keywords: Pentatropis nivalis, hepatoprotective, Carbontetrachloride, Silymarin

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