Research Articles

2021  |  Vol: 7(6)  |  Issue: 6 (November-December)  |  https://doi.org/10.31024/ajpp.2021.7.6.2

Effect of aqueous extract of Clerodendrum thomsoniae Linn. leaves on the onset of hyperlipidaemia and the inhibition of gain mass on wistar rats

Deutchoua Ngounou Eric Martial^1*, Mang Yannick Dimitry², Dongmo Faustin¹, Youdom Patrick³, Sokeng Dongmo Sélestin¹, Njintang Yanou Nicolas³

¹Department of Biological Sciences, Faculty of Science, University of Ngaoundere, PO Box 454, Ngaoundere-Cameroon

²Department of Tourism and Hotel Management, Higher Technical Teacher’s Training College of Ebolowa, University of Yaoundé I, PO Box 886, Ebolowa-Cameroon

³Department of Food Science and Nutrition, Physical and Chemistry Food Laboratory, ENSAI, University of Ngaoundere, PO Box 455, Ngaoundere-Cameroon

*Address for Corresponding author

Deutchoua Ngounou Eric Martial

Department of Biological Sciences, Faculty of Science, University of Ngaoundere, PO Box 454, Ngaoundere, Cameroon

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Abstra​ct

Background: The genus Clerodendrum is among the most important in the plants’ kingdom with many species known for their medicinal properties and among which Clerodendrum thomsoniae is well represented. Previous studies established hypolipidemic, antioxidant and antidiabetic properties of aqueous extract (AECT) of Clerodendrum thomsoniae. Objective: This study aimed at evaluating the effect of the AECT on the onset of hyperlipidaemia in wistar rats. Material and methods: Normal Wistar rats were administered AECT (312.5, 625 and 1250 mg/kg, p.o.) followed by feeding with high fat diet for five weeks. Lipid parameters such as total cholesterol (TC), Low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) levels were measured in serum. The modifications in the body mass, feed intake were evaluated. The results revealed that HFD induced an alteration in serum, lipid profile (triglyceride, cholesterol, HDL, and LDL) in negative control rats. Meanwhile in rats subjected to AECT (312.5, 625 and 1250 mg/Kg p.o) no significant changes were noticed with the normal control rats (p < 0.05). On the other hand, concerning body mass, no significant change was observed between the normal control and test rats. AECT showed the ability to prevent the onset of hyperlipidaemia in rats. Hence, it could be used in the management of cardiovascular diseases, obesity and metabolic syndrome.

Keywords: Clerodendrum thomsoniae, High fat diet, Cholesterol, hyperlipidaemia, antidiabetic