Ganga Raju M*, Kumara Swamy K.
*Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Telangana State, India
*Address for Corresponding author
Dr. M. Ganga Raju,
Professor and Head,
Department of Pharmacology, GRCP, Bachupally, Hyderabad. India
Objective: The present study was carried out to investigate the anti-inflammatory and antioxidant activity of methanolic extract of Cajanus cajan. Materials and Methods: The extract was evaluated for its in vivo anti-inflammatory activity by carrageenan induced paw oedema model using indomethacin as standard and in vitro anti-inflammatory activity by protein denaturation method using diclofenac sodium as standard. The extract was evaluated for its antioxidant activity by reducing power assay and hydrogen peroxide assay using ascorbic acid as standard. Results: The methanolic root extract of Cajanus cajan (MECC) significantly (p<0.05) inhibited the paw oedema volume. The extract significantly (p<0.05) protected protein membranes from denaturation. The extract also significantly scavenged the free radicals. The lupeol present in the extract targeted inflammatory signalling pathways there by exerting its anti-inflammatory activity. The phenolic constituents present in the extract might be responsible for its antioxidant activity as phenolics possess strong ability to inhibit oxidants and free radicals. Conclusion: From the above it is clear that MECC possess anti-inflammatory and antiradical activities.
Keywords: Cajanus cajan, anti-inflammatory, antiradical activities, diclofenac sodium