Aashaq Hussain Allaie1, Ravi Prakash Mishra1*, Aijaz Ahmad Ganaie1, Shoket Ali1, Ranu Singh2
1Environmental Biotechnology Lab. Department of P.G. Studies & Research in Biological Sciences, R. D. University, Jabalpur, India
2Department of Botany and Microbiology Mata Gujri Mahila Mahavidyalaya (Autonomous), Jabalpur, India
Ravi Prakash Mishra
Environmental Biotechnology Lab. Department of P.G. Studies & Research in Biological Sciences, R. D. University, Jabalpur, (M.P.) India
Objective: To make scientific validation of the ethanomedicinal Vitex negundo (Jacq.) in relation to urinary disorders. Methods: Antibacterial study was carried out on clinically isolated Catheter-associated urinary tract infections (CAUTI) infecting bacteria by disc diffusion method. Results: Among the two extracts tested against three different Catheter-associated urinary tract infections (CAUTIs) bacteria, methanolic extract was effective against E. coli with highest inhibition zone (27 mm) followed by P. aeruginosa with inhibition zone (20 mm) and K. pneumoniae with inhibition zone (19 mm), while, hexane extract also shows highest effective against E. coli with inhibition zone (29 mm) followed by P. aeruginosa with inhibition zone (23 mm) and K. pneumoniae with inhibition zone (16 mm). Preliminary phytochemical screening shows the presence of phytoconstituents viz alkaloids, glycosides, saponins, carbohydrates, proteins, amino acids, flavonoids, steroids, tannins. Conclusion: Based on the present study, along with previous studies, the ethanomedicinal use of Vitex negundo for the treatment of CAUTI has been scientifically validated.
Keywords: Vitex negunda, Phytochemical, Chaste tree, CAUTI