Research Articles

2017  |  Vol: 3(3)  |  Issue: 3(May-June)
A detailed study of Transition Metal Complexes of a Schiff base with its Physico-chemical properties by using an electrochemical method

Abhishek Ghara, Dr. Abhik Si, Mritunjoy Majumder, Anindya Bagchi *, Anusree Raha, Prosenjit Mukherjee, Monit Pal, Ranajoy Kr. Saha, Souvik Basu

Netaji Subhas Chandra Bose Institute of Pharmacy, West Bengal, India

*Corresponding Author

Anindya Bagchi

Assistant Professor

Netaji Subhas Chandra Bose Institute of Pharmacy, West Bengal, India

Mobile No: +91-9330954315.



Background: Activities of metal ions in biology have stimulated the development of metal based therapeutics. It has been found that biologically active compounds became more effective and bacteriostatic upon chelation with metal ions. Objective: The present work deals with the synthesis of metal (Cu and Zn) complexes derived from a novel Schiff base drug synthesized from urea and salicylaldehyde and its physico-chemical analysis was carried out to find out ligand- metal ratio of this complex in solution. Material and methods: For the determination of complexing nature of these complexes “Monovariation method (Mole ratio method/ Yoe-Jones Method)” have been used to ascertain the ligand-metal ratio in the complex. The stability constant of the formed complexes was calculated by molar conductance measurement using Modified Job’s method (Method of Continuous Variations). The analysis was carried out by using conductometry. To confirm metal-ligand ratio, conductometric titrations was been carried out at room temperature using analytical grade metal salts. Results and conclusion: Titrations were carried out with “systronics conductivity-meter” using dip type conductivity cell having cell constant 1 at room temperature. Data after the analysis showed the formation of 1:1 [M:L] ratio in the case of Cu ion and 1:3 [M:L] in the case Zn ion. The coordination behavior of the metal ions towards to the investigated Schiff base takes place through –C=N and –OH groups.

Keywords: Yoe-Jones Method, Conductometry, Modified Job’s method, Chelation, Metal ions.

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