Research Articles

2017  |  Vol: 3(3)  |  Issue: 3(May-June)
Preparation, Estimation and Validation of the parameters of the standard curve of Ibuprofen by comparative study

Anirban Tewari, Anindya Bagchi*, Anusree Raha, Prosenjit Mukherjee, Monit Pal

Netaji Subhas Chandra Bose Institute of Pharmacy, West Bengal, India

*Corresponding Author

Anindya Bagchi

Assistant Professor

Netaji Subhas Chandra Bose Institute of Pharmacy, West Bengal, India

Mobile No: +91-9330954315



Objective: The objective of present study was to study and validation of different parameters for Ibuprofen. Material and methods: UV spectrophotometric method for the comparative quantitative determination of Ibuprofen was developed for the validation of the prepared standard curve of the drug in two different conc. of same solvent (HCl). The parameters like linearity, accuracy, precision, limit of detection, limit of quantization, range, Robustness & Ruggedness were studied according to International Conference on Harmonization guidelines (ICH). The absorbance values were measured at 222 nm. Results and conclusion:  Results of the analysis were validated statistically and also by recovery studies. The proposed method can also be used for the reliable quantization of Ibuprofen in pharmaceutical formulation. In the UV spectroscopic method linearity over the concentration range of (100-600) ug/ml with a correlation coefficient 0.9972 (Solvent is 0.1N HCl) and 0.9937 (Solvent is 1N HCl) for (50-100) ug/ml were found out.

Keyword: Ibuprofen, ICH, Range, Concentration, LOD

Manuscript Management System
Submit Article Subscribe Most Popular Articles Join as Reviewer Email Alerts Open Access
Our Another Journal
Another Journal