Virupanagouda P. Patil1, Nanjappaiah Hankuntimath1, Chandrashekhar V. Mangannavar2, Shivakumar Hugar1*
1P.G. Department. of Pharmacology, BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapur-586103. Karnataka. India.
2P.G. Department. of Pharmacology, BVVS’s HSK College of Pharmacy, Bagalkot- 587101. Karnataka. India.
*Address for Corresponding author.
Dr. Shivakumar Hugar
Prof. and Head
P.G. Dept. of Pharmacology,
BLDEA’s SSM College of Pharmacy and Research Centre, Vijayapur-586103
Objective: Cocos nucifera is one among the ingredients of polyherbal formulation used for the management of stress by Ayurvedic practioners. Hence, the present study was undertaken to scientifically validate antistress effect of Cocos nucifera in immobilization stress model. Materials and Methods: Rats were administered graded doses of ethanolic extract of Cocos nucifera endocarp for 10 days. All the animals were subjected for immobilization stress and its antistress efficacy was assessed by estimating various parameters such as hematology, biochemicals like serum glucose, cholesterol, triglycerides and blood urea nitrogen (BUN), brain neurotransmitters, organs weight and body weight. Results: Stressed rats demonstrated altered values of all these parameters. Ethanolic extract of Cocos nucifera endocarp exhibited significant anti-stress activity by restoration of all the altered values. Conclusion: Present findings validate its use in Aurvedic system of medicine.
Keywords: Antistress, Cocos nucifera, immobilization stress, phenolic content, flavonoid content