Ajay Kumar Shukla*, Ram Singh Bishnoi, Manish Kumar, C.P. Jain
Department of Pharmaceutical Sciences, Mohanlal Sukhadia University, Udaipur, Rajasthan, India
*Address for Corresponding Author:
Mr. Ajay Kumar Shukla,
Department of Pharmaceutical Sciences,
Mohanlal Sukhadia University, Udaipur, Rajasthan, India
Objective: The objective of the present work was to investigate the film coating potential of Fenugreek seed gum (FSG), Tamarind seed gum (TSG), using paracetamol as a model drug. Materials and Methods: Fenugreek seed gum (FSG), tamarind seed gum (TSG), paracetamol tablets, hydroxypropylmethylcellulose (HPMC) and sodium alginate (SA). Core tablets of paracetamol were obtained from a pharmacy shop in the local market and were evaluated for weight, diameters, thickness, hardness, friability, and disintegration time. The core tablets were coated using 2% w/v solution of TSG, MTSG, FSG, MFSG and the in-vitro release rate of drug from these coated tablets was compared to the release rate of drug from the tablets coated with 2% w/v of HPMC. Results: The tablets coated with natural and modified tamarind seed gum, separately. The coated tablets are release the drug up to 10 hrs and 11 hrs, respectively and natural and modified fenugreek seed gum release the drug up to 7 hrs and 9 hrs respectively. The tablets coated with HPMC released the drug up to 14 hrs. The drug release profile of tablets coated with modified tamarind seed gum was comparable to the release profile of tablets coated with HPMC. Conclusion: On the basis of the drug release profile, it is concluded that FSG and TSG can be used as release rate controlling membrane of natural origin.
Keywords: Fenugreek seed gum, pharmaceutical excipient, natural polymer