Research Articles

2018  |  Vol: 4(6)  |  Issue: 6 (November-December)  |
Evaluation of rationality, efficacy and tolerability of antimicrobials prescribed for acute pharyngitis at a teaching hospital in India

Tamilisetti Vidya Sagar1, Sanjay Kumar2*, Shantilata Patnaik3                

1Assistant Professor, Department of Pharmacology, GSL Medical College, Rajahmundry, India

2Professor, Department of Pharmacology, GSL Medical College, Rajahmundry, India

3Professor, Department of Pharmacology, IMS & SUM Hospital, SOA University, Bhubaneswar, India

*Address for Corresponding author

Dr Sanjay Kumar,

Professor, Department of Pharmacology,

GSL Medical College, Rajahmundry, India, Pin: 533294


Objective: To evaluate rational drug use in acute pharyngitis and to assess efficacy and tolerability of antimicrobials used for acute pharyngitis in a tertiary care hospital. Materials and Methods: This is a descriptive and observational study, observed participants without providing any interventions related to treatment prescribed and then results are presented descriptively. Patients were grouped based on aetiology of acute pharyngitis, determined by Centor score and data were obtained from medical records, interviews and results of follow-up visits, data were analysed descriptively to conclude event of irrational use of drugs, proportion of antibiotic prescriptions and impact of irrational use of drugs in pharyngitis. The results were depicted in the form of tables and figures. Microsoft word and excel are used to generate figures and tables. Patient compliance to the prescribed medications was assessed by pill count method/recovering empty packets. Results: As much as 80% acute pharyngitis patients received antibiotics, but only 8% of patients showed indications warranting their use. In this study, the appropriate duration of treatment was only found in 0.5% of patients, most (50%) received antibiotics for 5 days, it was found that corticosteroids were prescribed to about 20 of patients, furthermore, result of follow-up showed that 50% patients adhered to regimen of antibiotics prescribed by doctors and 40% did not comply, adverse effects of therapy were reported in 20(25%) patients who receive an antibiotic, majority of patients experienced side-effects in the form of dizziness, heartburn, headache and diarrhoea. Conclusion: Acute pharyngitis is expected to be main cause of inappropriate use of antibiotics in clinical practice, cautious and judicious use of antibiotics will reduce burden of multi-drug resistance and thereby enabling better patient management and limiting resultant morbidity, there is a need to increase awareness of use of standard treatment guidelines to encourage rational drug utilization.

Keywords: Pharyngitis, Centor score, Amoxicillin, antibiotics, antimicrobials, rational drug use

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