Review Articles

2018  |  Vol: 4(5)  |  Issue: 5 (September- October)  |  https://doi.org/10.31024/ajpp.2018.4.5.1
Curcuma longa for Arthritis pain: Systematic review of randomized controlled trial study

Rizaldy Taslim Pinzon*, Rosa De Lima Renita Sanyasi

Faculty of Medicine Duta Wacana Christian University, Yogyakarta, Indonesia

*Address for Corresponding Author

Rizaldy Taslim Pinzon

Dr. Wahidin Sudirohusodo Street No. 5-25, Yogyakarta, Indonesia, 55224

Abstract

Background: Curcuma longa is commonly known as turmeric constituents include the three curcuminoids: curcumin, demethoxycurcumin, and bisdemethoxycurcumin. Curcumin has anti-inflammatory and analgetic action. It is a promising medication to alleviate pain among arthritic patients. Objective: This systematic review aimed to identify the benefit of Curcuma longa in arthritis pain. Materials and Methods: Systematic research was conducted by using PubMed and Cochrane with following terms to search: “Curcuma longa”, “curcumin”, and “turmeric”. The quality of randomized controlled trial (RCT) study is assessed by using the Jadad score and the selected studies were reviewed by using PRISMA checklist as the guidance. Results: There were 98 studies related to Curcuma longa and arthritis pain. After screening and checking for the eligibility, remains 7 studies. All studies have a good quality indicated by Jadad score of  ≥3. The subjects in most studies were osteoarthritis (OA) patients and compared curcumin with placebo. Subjects in all studies dominated by female. VAS is the most common scale to assess the degree of pain. Curcumin was considered to be safe in patients with arthritis. It also improves the intensity of pain in all studies. Conclusion: Curcuma longa proved to be effective to reduce pain among arthritic patients. It is also found to be safe without any serious adverse event.

Keywords: Curcuma longa, inflamation, pain, curcumin, turmeric

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