Assessment of antidepressant and anxiolytic activities of aqueous extract of Daucus carota Peel
Parveen Nisha, Vikash Kumar Mishra, Nitin Nema*
Sagar Institute of Pharmaceutical Sciences, Sagar, Madhya Pradesh, India
*Address For correspondence
Dr. Nitin Nema
Associate Professor,
Sagar Institute of Pharmaceutical Sciences, Sagar, Madhya Pradesh, India
Abstract
Objective: Aim of present study was to evaluate antidepressant and anxiolytic activities of Daucus carota in albino mice. Material and Methods: In present study, aqueous extract of Daucus carota peels (AEDC) at doses of 75 mg/kg BW (DCE-A) and 150 mg/kg BW (DCE-B) were evaluated for antidepressant and anxiolytic activities. Albino mice of either sex (25-30 g) were used for the study. Toxicity studies of AEDC were performed according to Organisation for Economic Co-operation and Development (OECD) guidelines. Results and Conclusion: Imipramine was taken as standard drug in forced swimming test (FST) test where DCE-B showed better reduction in the duration of immobility and increases the number of counts rotation more as compared lower dose DCE-A. In hole board test DCE-B showed about same level of response and potency as standard drug diazepam. In elevated plus maze test, DCE-B found to better in average time spent in open arm, decreasing time in the closed arm and increases number of entries in open arm and decreases the closed arm as compared to DCE-A.
Keywords: Antidepressant activity, Anxiolytic activity, Daucus carota, Forced swimming test with activity wheel (FST), Elevated plus maze test (EPM), Hole board test (HBT)
