Review Articles

2020  |  Vol: 6(Articles in Press)  |  Issue: 3 (May-June)  |  https://doi.org/10.31024/ajpp.2020.6.3.1
Recent updates on analytical methods for detection of cyanide in human blood

Poonam Yadav*, M. P. Goutam

Shri Vaishnav Institute of forensic science, Shri Vaishnav Vidhyapeeth Vishwavidyalaya, Indore (M.P.), India

 

*Address for Corresponding Author

Poonam Yadav,

Assistant Professor, Shri Vaishnav Institute of forensic science, Shri Vaishnav Vidhyapeeth Vishwavidyalaya, Indore (M.P.), India


Abstract

Cyanide is a toxic chemical; its poisoning may be as a result of natural processes and/or legal or illicit uses. Cyanide exposure can be verified by analysis of cyanide or one of its breakdown products from biological samples. This verification may be important for medical, police & forensic investigation purposes. Various reported methods for determination of cyanide exposure for humans in biological matrix but blood is found to be the most versatile biological sample used to determine cyanide exposure because the analyses of cyanide, thiocyanate, ATCA, and cyanide-protein adducts can each be performed on blood samples. In this review efforts have been made to summarise the development of procedures to enable quantitation of cyanide ions or its break down products in blood samples that can provide an up to date reference document to the forensic toxicologists.

Keywords: Analytical techniques, Colorimetry, Fluorimetry, Spectrophotometric method, Capillary electrophoretic determination, High Performance Liquid Chromatography, Capillary gas chromatography, Gas chromatography-mass spectrometry, Liquid chromatography–tandem mass spectrometry

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