Research Articles

2018  |  Vol: 4(1)  |  Issue: 1(January-February)  |  https://doi.org/10.31024/ajpp.2018.4.1.8
Determination of Rosuvastatin Calcium in bulk and Pharmaceutical dosage forms by using UV-Spectrophotometric method

Harjeet Singh1*, Ram Dayal Gupta2, Girendra Gautam3

1Department of pharmacy, Bhagwant University, Ajmer 305004, Rajasthan, India

2Department of Pharmaceutics, H.R. Institute of Pharmacy, Morta, Ghaziabad 201003, Uttar Pradesh, India

3Department of pharmacy, Bhagwant University, Ajmer 305004, Rajasthan, India

*Corresponding Author

Harjeet Singh

Department of Pharmacy, Bhagwant University, Ajmer

Rajasthan-305004

Abstract

Objective: The aim of the present work was to develop a simple and sensitive UV spectrophotometric method for the estimation of rosuvastatin calcium in bulk and in pharmaceutical dosage form. Material and methods: Rosuvastatin calcium exhibits maximum absorbance at 244 nm with apparent molar absorptivity of 7.1862 × 104 L/mol.cm in methanol as solvent. Beer’s law was found to be obeyed in the concentration range 2-18 µg /ml for rosuvastatin calcium. Result and discussion: The results of the study demonstrated that the developed procedure was accurate, precise and economical. This method is further extended to pharmaceutical dosage form. Conclusion: In this method, no interference from any pharmaceutical additives and diluents were found. The validation of the analysis was done by statistically and recovery studies.

Keywords: Rosuvastatin calcium, UV spectrophotometric method, Validation

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