Research Articles

2017  |  Vol: 3(6)  |  Issue: 6 (November-December)
Synthesis and biological evaluation of some novel heterocyclic Chalcone derivatives

A. Asrar Ahamed, M. Mohamed Sihabudeen*

PG and Research Department of Chemistry, Jamal Mohamed College (Autonomous),

Affiliated to Bharathidasan University, Tiruchirappalli, Tamilnadu, India.

*Address for Corresponding Author

Dr. M. Mohamed Sihabudeen

Additional Vice Principal and Head,

PG and Research Department of Chemistry, Jamal Mohamed College (Autonomous),

Tiruchirappalli, Tamilnadu, India. Cell: 9842380379 

Abstract

Objective: The chemistry of chalcones has generated intensive scientific studies throughout the world. In recent years, a variety of chalconilides have been reviewed for their cycotoxic, anticancer chemopreventive and mutagenic as well as antiviral, insecticidal and enzyme inhibitory properties. Condensation of aromatic aldehydes and aryl anilides in presence of suitable condensing agents gave chalcone derivatives. These types of chalcones are called chalconoids. Materials and methods: Heteroatoms such as N and O containing chalconoids have exhibited anti-inflammatory, antioxidant, analgesic, antitubercular and antibacterial activities etc.  Therefore an attempt has been made to synthesize chalcones by the condensation of N-phenyl acetanilides with substituted Indole-3-carbaldehydes. The resulting chalcones (A1) after purification have been converted into substituted pyrazole derivatives (A2 & A3) by reaction with hydrazine hydrate and isonicotinylhydrazide. All these compounds were characterized and confirmed by TLC, elemental analysis, IR, 1H and 13C NMR. All these compounds were screened for their potential antimicrobial activity. Results: These novel compounds showed optimum activities at 25, 50, 75 and 100 μl concentrations against antibacterial gram positive Staphylococcus aureus and Bacillus subtilis, gram negative Escherichia coli and Enterobacter microbes, antifungal Aspergillus niger and Candela albicans. Conclusion: These compounds containing N-phenyl acetanilide group were found to show potent analgesic and antimicrobial activities. These findings prompted us to synthesize these chalconalides which are found to be the potential antimicrobial agents.

Keywords: Chalcone, acetanilide, isonicotinylhydrazide, antimicrobial activities

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