Research Articles

2019  |  Vol: 5(4)  |  Issue: 4 (July- August)  |  https://doi.org/10.31024/ajpp.2019.5.4.19
Preparation and evaluation of gastroretentive hydrogel beads of Cefdinir by ionotropic gelation method

M. Y. Khalifa1*, M. A. Saleem2, Shaikh Siraj N.1, Huzaifa Patel3

1Department of Pharmaceutics, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415

2Department of Pharmaceutics, Luqman College of Pharmacy, Gulbarga Karnataka, India

3Department of Pharmaceutics, Jamia College of Pharmacy Akkalkuwa, Nandurbar, Maharashtra, India-425415

*Address for Correspondence:

M. Y. Khalifa

Asst. Professor, Ali-Allana College of Pharmacy Akkalkuwa, Nandurbar, and Maharashtra, India

Abstract

Objective: The purpose of the present study was to develop and evaluate gastroretentive hydrogel beads of Cefdinir using polymers like Sodium alginate and Sodium CMC by ionotropic gelation method using Calcium carbonate or sodium bicarbonate as a gas forming agent. Materials and Methods: Twelve formulated beads evaluated physically in terms of surface morphology, bead size, entrapment efficiency, floating characteristics, Fourier transform infrared spectroscopy, in vitro swelling, and in vitro drug release and stability studies.  Results: The surface morphology revealed that the prepared beads are spherical, having rough and dense surface with microscopic cracks and wrinkles on the surface. According to nature of coagulation medium the shape of beads was changed. Formulations F5 shows higher drug entrapment efficiency (i.e. 94.60%) suggesting that the ionotropic gelation method is effective for the entrapment of Cefdinir. All the beads formulation remained float throughout the study up to 24 h with the range of 62.25-96.40% suggesting that calcium carbonate and sodium bicarbonate can be used as buoyant. All the beads show good swelling up to 12 hrs in 0.1 N HCL. The swelling followed values in order of sodium carboxy methyl cellulose > sodium alginate. The in vitro drug release indicated that increase the concentration of gas forming agent increase the drug release and drug release followed values in order of sodium alginate > sodium CMC. Also increase in concentration of the polymer resulted in decreased drug release. Conclusion:  It can be concluded that the floating beads of cefdinir can be prepared by using CaCO3 and NaHCO3as buoyant along with hydrogel forming polymer like sodium alginate and sodium carboxy methylcellulose as a release modifier for improved oral bioavailability of Cefdinir.

Keywords: Cefdinir, ionotropic gelation, gas forming agent, oil entrapment, sodium alginate, sodium carboxy methyl cellulose

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