Research Articles

2019  |  Vol: 5(6)  |  Issue: 6 (November-December)  |
Preclinical evaluation of anxiolytic activity of Enhydra Flactuans leaves on albino Wistar rats

Kousik Saha*, Mriganka Sekhar Bala, Trisha Sen, Mrityunjoy Majumdar

Department of Pharmacology, Netaji Subhas Chandra Bose Institute of Pharmacy, West Bengal, India

*Address for Corresponding Author

Kousik Saha

Department of Pharmacology

Netaji Subhas Chandra Bose Institute of Pharmacy,

Roypara, Tatla, Chakdaha, Nadia, Pin: 741222, West Bengal, India



Objective: The goal of the present study was to evaluate an extract of the leaves of Enhydra flactuans (EF) for its anxiolytic activity using Albino wistar rat. Materials and methods: For this investigation the hydroalcoholic extract of the leaves of the plant Enhydra fluctuans was prepared. In present study different models namely Elevated Plus Maze test, Social Interaction test and Rota Rod test were performed to evaluate the anxiolytic activity. Clonazepam was used as a standard drug. Results: EF (2.5 and 5 mg/kg, i.p.) was administered to the animals and the results were compared by those elicited by the standard drug clonazepam (4 mg/kg, i.p.) for anxiolytic study. In all the models EF has shown significant anxiolytic property in dose dependent manner. Conclusion: By focusing on this it can be assumed that Enhydra fluctuans also have the same activity as the folk use support the same. 

Keywords: Enhydra fluctuans, anxiolytic, elevated plus maze test, social interaction test, rota rod test, Clonazepam

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