Vinoth Kumar P1, Rajalakshmi A.N.1*, Stephen P2
1Department of Pharmaceutics, College of Pharmacy, Mother Theresa Postgraduate And Research Institute of Health Sciences, Puducherry-605006
2Formulation Research and Development, SaiMirra Innopharm Pvt Ltd., Chennai.
*Address for correspondence:
A. N. Rajalakshmi,
HOD, Department of Pharmaceutics,
College Of Pharmacy,
Mother Theresa Postgraduate and Research Institute of Health Sciences, Puducherry - 605006 India
Objective: The aim of the present study was to enhance the dissolution of a practically insoluble Nifedipine by liquisolid compact technique and to enhance the onset of action by Orodispersible tablet technique. Materials and methods: Orodispersible liquisolid compact of Nifedipine were prepared by direct compression method using PEG 400, Microcrystalline cellulose PH 102 and Aerosil 200 as non-volatile solvent, carrier, coating material respectively and co-processed superdisintegrants (Crosspovidone and croscarmellose sodium) in the ratio of 1:1, 1:2, 1:3. The liquisolid compacts were characterized by X-ray powder diffraction, Scanning electron microscopy and FT-IR studies. The statistical analysis for stability studies was carried out by Student’s t-test (SPSS SOFTWARE VERSION 16.0) at a level of 𝑃 = 0.05. Results and conclusion: Orodispersible liquisolid compacts of Nifedipine tablets (F3) containing co-processed superdisintegrants in the ratio of 1:3 exhibits quick disintegration time and maximum drug release. No significant difference (𝑃 value 0.969 > 0.05) was found in the dissolution rate of the stored formulation when compared with freshly prepared formulation. Conclusion: This research work may be useful to formulate Orodispersible tablets using Liquisolid technique which may give rapid onset of action by rapid absorption, maximize efficacy and hence increase patient compliance.
Keywords: Liquisolid compacts, poorly soluble drugs, super-disintegrants, dissolution rate