Brahamdutt1, Vipan Kumar Kamboj1, Arun Kumar1, Mangal Sain Hooda2, Pradeep Sangwan2*
1Department of Pharmaceutical Sciences, Maharishi Dayanand University, Rohtak, Haryana, Pin-124001, India
2Janta College of Pharmacy, Butana, Sonepat, Haryana, Pin-131302, India
*Address for Corresponding Author
Janta College of Pharmacy, Butana, Sonepat, Haryana, Pin 131302, India
In the modern system of drug delivery, even after several efforts by the scientists, the chief key issue remains the efficient and effective amount of drug delivery at particular site. Due to the low residence time of API’s at the required site, leads to the poor bioavailability of drugs in the conventional drug delivery systems. At present nanotechnology is the emerging field for delivery of drugs at size of nano-scale and very effective in sustained and targeted delivery of medicines i.e. polyplexes (DNA/polycation complexes), block copolymer micelles and nano-gels etc. In the human trials, polymeric micelles have been found to be very convincing method for delivery of anticancer drugs. Selection of suitable method of preparation remain an important aspect as particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamics properties of various types of drug molecules. Several methods to prepare polymeric nanoparticles have been developed and these techniques are classified according to whether the particle formation involves a polymerization reaction or nanoparticles form directly from a macromolecule or preformed polymer.
Keywords: Nanotechnology, nanomaterials, solid lipid nanoparticles, liposomes, microparticles