Research Articles

2018  |  Vol: 4(1)  |  Issue: 1(January-February)  |
Preclinical evaluation of anti-rheumatoid effect of chrysin in Freund's complete adjuvant induced arthritis in Wistar Albino rats

Vishnu R.1, Krishnan R.2

1Assistant Professor, Department of Pharmacology, PK Das Institute of Medical Sciences, Vaniamkulam, Kerala, India

2Consultant Physiatrist, Indo American Hospital, Brain and Spine Center, Vaikom, Kerala, India

Corresponding author

Dr. Vishnu R.

Assistant Professor

Department of Pharmacology

PK Das Institute of Medical Sciences, Vaniamkulam, Kerala, India

Mobile No: +91-9207320999


Background: Arthritis is a universal disorder, affecting both sexes and all races. Every human being who lives long enough will have it somewhere, in some degree. Arthritis is one of the leading causes of disability in the world. Objective: The present study aimed to find the anti-rheumatoid effect of Chrysin in Freund’s complete adjuvant induced arthritis in Wistar albino rats. Materials and methods: Thirty rats were divided into 5 groups each of 6 rats. G-I (Normal control), G-II (Freund’s complete adjuvant), G-III (Dexamethasone 0.5mg/kg), G-IV (Chrysin 50 mg/kg) and G-V (Chrysin 100 mg/kg). All rats were treated with their respective drugs for 56 days. Blood was collected from each rat for the estimation of serum rheumatoid factor, C-reactive protein, erythrocyte sedimentation rate. Results: Rats treated with control showed significant difference with other groups. Dexamethasone significantly reduced the rheumatic parameters. High dose of chrsin groups showed significant difference compared to control and standard drugs. Conclusion: From the study observations it can be concluded that administration of Chrysin can significantly reduced the symptoms of rheumatoid arthritis. Further studies required to find the mechanism of action of the test drug.  

Keywords: Arthritis, Arthritic index, C-reactive protein, Dexamethasone, Freund’s, inflammation

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