Research Articles

2019  |  Vol: 5(6)  |  Issue: 6 (November-December)  |  https://doi.org/10.31024/ajpp.2019.5.6.2
Evaluation of diuretic potential of petroleum ether extract of Dendrophthoe falcata leaves in wistar rats

P. Smana Reddy*, B. Sowmya, N. Sravani, P. Sandhya, Ch. Krishna Mohan

School of Pharmacy, Nalla Narasimha Reddy Education Society’s Group of Institutions, Hyderabad, Telangana, India

Address for Corresponding Author

P. Smana Reddy,

Assistant Professor,

Department of Pharmacology,

Nalla Narasimha Reddy Education Society’s Group of Institutions, Chowdariguda (V), Ghatkesar (M), Medchal (D), Telangana, 500088 India

Abstract

Objective: The present study was undertaken to establish the diuretic activity of petroleum ether extract of leaves of Dendrophthoe falcata (EEDF) in wistar rats. Materials and Methods: The Petroleum ether extract of leaves of Dendrophthoe falcata were administered to experimental rats orally at doses of 250mg/kg and 500mg/kg and compared with furosemide (20mg/kg., p.o) as the standard. The parameters measured for diuretic activity were total urine volume, urine concentration electrolytes such as sodium, potassium, and chloride. Results and Conclusion: The rats treated with EEDF at doses 250mg/kg and 500mg/kg showed higher urinary output when compared to respective control and also showed dose dependent increase in the excretion of electrolytes when compared to the control group. The extract has diuretic effect supporting the ethno-pharmacological use as diuretics. This effect may be explored in the use of the plant in the management of some cardiovascular diseases.

Keywords: Dendrophthoe falcata, diuretic action, diuretic index, lipschitz value

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