Research Articles

2017  |  Vol: 3(6)  |  Issue: 6 (November-December)

Synthesis, characterization and biological evaluations of some 2,6-bis(6-substituted-2H-chromen-2-one)-4-(2,5-disubstituted-1H-indol)pyridines and their Molecular docking studies

Anil S. Rathod, Shivakumar S. Godipurge, Jaiprakash S. Biradar*

Department of Chemistry, Gulbarga University, Kalaburagi 585 106 Karnataka, India

*Address for Corresponding Author

Dr. Jaiprakash S. Biradar

Department of Chemistry, Gulbarga University, Kalaburagi -585 106

Karnataka, India

Tel.: +91-9449235534; Fax: +91-8472-248632

Abstract

Objective: The aim of this study was to synthesize 2,6-bis (6-substituted-2H-chromen-2-one)-4-(2,5-disubstituted-1H-indol)pyridine derivatives as potent biological agents and their molecular docking studies. Material and methods: The structure of the newly synthesized compounds was confirmed by FT-IR, ¹HNMR and Mass spectroscopic methods and to evaluate the biological studies like antimicrobial and antioxidant activities. The mode of action of these active compounds was carried out by molecular docking studies. Results and Conclusion: Among all the synthesized compounds tested 3a was found to be the most active with, S. aureus, 3b with S. aureus, E. coli, 3e with E. coli, E. fecalis, 3h with S. typhi and 3d, 3h with A. nizer at 100µg/ml and some of the compounds have shown promising antioxidant properties.

Keywords: Indole, coumarin, pyridine, antimicrobial, antioxidant and molecular docking