Research Articles

2019  |  Vol: 5(4)  |  Issue: 4 (July- August)  |  https://doi.org/10.31024/ajpp.2019.5.4.25
Effect of Pterostilbene on cardiac oxidative stress on high-fat diet-fed and Streptozotocin-induced type 2 diabetic mice

Gunaseelan Thangasamy, Leelavinothan Pari*, Paari Ellappan, Kannan Duraisamy

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India

*Address for Corresponding Author

Dr. L. Pari, Ph.D.

Professor

Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar – 608 002, Tamilnadu, India

Abstract

Objective: Diabetes is a metabolic disorder characterized by enhanced production of free radicals hence oxidative stress. The aim of this study was to evaluate the activity of cardiac and antioxidant enzymes in high-fat diet-fed and streptozotocin-induced type 2 diabetic mice. Material and methods: The experimental study period was 16 weeks. C57BL6/J mice were fed a normal diet, normal diet with Pterostilbene (PTS), high-fat diet (HFD) and streptozotocin injection (10th week only), diabetic mice with PTS for last 6 weeks. Diabetic mice had high level of cardiac total cholesterol, triglycerides and free fatty acids level. Results and conclusion: Cardiac markers such as AST, CK-MB and LDH levels were significantly increased in diabetic mice. The activity level of enzymic (SOD, CAT and GPx) and non-enzymic antioxidant (Vitamin C, E and GSH) were lower diabetic mice. The levels of lipid peroxidation markers significantly increased in heart tissues. Treatment with PTS at a dose of 40mg/Kg BW significantly improved the parameters. This study suggests that PTS could be effective in improving cardiac dyslipidemia and antioxidant status in type 2 diabetes.

Keywords: Pterostilbene, high-fat diet, streptozotocin, cardiac markers, type 2 diabetes

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