Research Articles

2019  |  Vol: 5(4)  |  Issue: 4 (July- August)  |
Effect of Pterostilbene on cardiac oxidative stress on high-fat diet-fed and Streptozotocin-induced type 2 diabetic mice

Gunaseelan Thangasamy, Leelavinothan Pari*, Paari Ellappan, Kannan Duraisamy

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar - 608 002, Tamilnadu, India

*Address for Corresponding Author

Dr. L. Pari, Ph.D.


Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar – 608 002, Tamilnadu, India


Objective: Diabetes is a metabolic disorder characterized by enhanced production of free radicals hence oxidative stress. The aim of this study was to evaluate the activity of cardiac and antioxidant enzymes in high-fat diet-fed and streptozotocin-induced type 2 diabetic mice. Material and methods: The experimental study period was 16 weeks. C57BL6/J mice were fed a normal diet, normal diet with Pterostilbene (PTS), high-fat diet (HFD) and streptozotocin injection (10th week only), diabetic mice with PTS for last 6 weeks. Diabetic mice had high level of cardiac total cholesterol, triglycerides and free fatty acids level. Results and conclusion: Cardiac markers such as AST, CK-MB and LDH levels were significantly increased in diabetic mice. The activity level of enzymic (SOD, CAT and GPx) and non-enzymic antioxidant (Vitamin C, E and GSH) were lower diabetic mice. The levels of lipid peroxidation markers significantly increased in heart tissues. Treatment with PTS at a dose of 40mg/Kg BW significantly improved the parameters. This study suggests that PTS could be effective in improving cardiac dyslipidemia and antioxidant status in type 2 diabetes.

Keywords: Pterostilbene, high-fat diet, streptozotocin, cardiac markers, type 2 diabetes

Manuscript Management System
Submit Article Subscribe Most Popular Articles Join as Reviewer Email Alerts Open Access
Our Another Journal
Another Journal
Call for Paper in Special Issue on

Call for Paper in Special Issue on