Short Communication

2019  |  Vol: 5(5)  |  Issue: 5(September- October)  |  https://doi.org/10.31024/ajpp.2019.5.5.28
Role of Kaempferol on gemcitabine lipid interaction in goat liver model

Sarbani Dey Ray

Department of Pharmaceutical Sciences, Assam University, Silchar 788011, India

*Corresponding author

Sarbani Dey Ray

Department of Pharmaceutical Sciences, Assam University, Silchar 788011, India

Abstract

Objective: The study was done in vitro to explore antiperoxidative potential of kaempferol on gemcitabine-induced lipid peroxidation. Material and methods: Goat liver tissue homogenate was used as source of lipid. Two common laboratory markers such as 4-hydroxy-2-nonenal and reduced glutathione were used for the model. Results and conclusion: It was observed that for 4-HNE content, gemcitabine-treated group is statistically different from gemcitabine and kaempferol-treated and only kaempferol-treated groups, but there is no difference between gemcitabine and kaempferol-treated and only kaempferol-treated groups. For GSH content gemcitabine-treated group, gemcitabine and kaempferol-treated and only kaempferol-treated groups are statistically significantly different from each other. The result showed that gemcitabine has the ability to induce lipid peroxidation to a significant extent and it was also found that kaempferol has the ability to suppress the gemcitabine-induced toxicity. 

Keywords: Gemcitabine, kaempferol, lipid peroxidation, 4-hydroxy-2-nonenal, reduced glutathione

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