Yogesh Porea, Vaishnavi Mangrule*b, Madhuri Manec, Atul Chopaded
aDepartment of Pharmaceutical Chemistry, Government College of Pharmacy, Ratnagiri, Maharashtra, 415 612, India.
bDepartment of Pharmaceutical Chemistry, Government College of Pharmacy, Karad, Maharashtra, 415 124, India.
cDepartment of Biopharmaceutics, Government College of Pharmacy, Karad, Maharashtra, 415124, India.
dDepartment of Pharmacology, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, 415 404, India.
Department of Pharmaceutical Chemistry,
Government College of Pharmacy, Karad, Maharashtra, 415 124, India, Tel: +91-02164-271196; Fax: +91-02164-271196
Objective: In the present study, an effort was made to prepare active pharmaceutical ingredient (API) based ionic liquids (ILs) by combination of anionic diclofenac and cationic tetrabutylammonium bromide. The solid form of the low water soluble drug was converted into its liquid salt form to improve physicochemical properties and evaluate biological activity. Materials and methods: ILs were prepared applying solvent evaporation method using acetone as solvent in 1:1 molar ratio. The formation of ILs was confirmed analytically by differential scanning calorimetry (DSC), Fourier transformation-infrared spectroscopy (FTIR) and X-ray powder diffractometry (XRPD). ILs were subsequently assessed for their physicochemical properties and anti-inflammatory activity. Results: The physicochemical parameters like solubility, dissolution and log P of IL were not significantly different as compared to diclofenac. The sodium salt of diclofenac and liquid salt of diclofenac showed similar anti-inflammatory activity and also found to be less than pure diclofenac upon evaluation by carrageenan induced rat paw edema method. Conclusion: It could be concluded that ILs of diclofenac could be prepared, unfortunately possessing non significant improvement in their physicochemical and biological performance.
Keywords: Diclofenac, ionic liquids, tetrabutylammonium bromide, physicochemical studies, anti-inflammatory activity