Anant Srivastava*, Rishabh Singh
Faizullaganj, Lucknow 226020, Uttar Pradesh, India
*Address for Corresponding Author
Department of Pharmacology,
Hygia Institute of Pharmaceutical Education and Research, AKTU University, Lucknow-226020, India
Objective: To study the synergetic effect of Melatonin and Simvastatin on brain of albino mice of Swiss strain. Materials and methods: The neuroprotective activity was studied in Lipopolysaccharides (LPS) and Streptozotocin (STZ) induced learning and memory deficit model. In this combined neuroprotective effect of melatonin and simvastatin against LPS and STZ was investigated the synergistic effect. Neuroprotective activity was evaluated by comparing behavioural (learning and memory) and biochemical (GSH, MDA, Cholinesterases) parameters. Results and discussion: There was significant decrease in MDA level and AChE level, as compare to disease group in Melatonin (**p<0.001) and Simvastatin (*p<0.05), Melatonin + Simvastatin (***p<0.001) and significant increase in GSH level respectively, in LPS and STZ memory impairment model. There was significant decrease in escape latency time and no. of crossing behavior in all groups in comparison of session 1-5 except the disease group in LPS and STZ model. Conclusion: Data indicates that combined administration of melatonin and simvastatin improve the behavioral and biochemical parameters in comparison to the administration of their individual doses. Biochemical parameters showed significant decrease (**p<0.01) in MDA level, AChE level and increase in (***p<0.001) GSH level which is equivalent to standard drug.
Keywords: Neuroprotective, synergistic, intracerebroventricular, Simvastatin, Melatonin