Research Articles

2016  |  Vol: 2(3)  |  Issue: 3 (May- June)
Study of Combined Tulsi extract and Cinnamon oil to reduce hypercholesterolemia in dyslipidemic rats

Akshay Javalgikar1*, Nitin Mahurkar,2 Aarti Malpani,3 Keerthi Karri4

1Department Of Pharmacology, Sahyadri College of Pharmacy, Methwade-413307, Maharashtra, India

2,3,4Department of Pharmacology, H.K.E.S’s MTRIPS, Kalaburagi- 585 105, Karnataka, India

*Address for correspondence author

Mr. Akshay Javalgikar

Department of Pharmacology,

Sahyadri college of Pharmacy,

Methwade-413307, Maharashtra, India

Abstract

Objectives: The studies were intended to investigate the possible antihyperlipidemic effect of tulsi and cinnamon oil in Triton induced hyperlipidemic rats. Materials and methods: Tulsi and cinnamon oil were evaluated for antihyperlipidemic activity by using Triton induced hyperlipidemia model in male Wistar albino rats (200-250g), A comparison was also made between the action of tulsi (0.5 mg/kg b.w) and cinnamon oil extracts(1.8mg/200g b.w) with antihyperlipidemic drug Atorvastatin (0.18mg/200g). Parameters assessed were body weight, total cholesterol, triglyceride, HDL-C, LDL-C. The results of the study were suggested by mean ± SEM. Statistical significance of data was assessed by one way analysis of variance (ANOVA) followed by a comparison between different groups using “Tukey - Kramer” test. Results: Oral administration of 0.5 mg/kg of tulsi with dist. water and Cinnamon oil of 1.8 mg/200g suspended in tween80 solution exhibited significant reduction (P ˂ 0.01) in serum biochemical parameters, the Serum parameters such as total Cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL) levels were decreased and an increase in high density lipoprotein (HDL) levels in hyperlipidemic rats of triton model was observed as compared to hyperlipidemic positive control. The results are statistically significant. Conclusion: The results demonstrated that tulsi and cinnamon oil extracts possessed significant antihyperlipidemic activity.

Keywords: Tulsi oil, Cinnamon oil, Atorvastatin, Triton x-100, Hyperlipidemia

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