Research Articles

2020  |  Vol: 6(6)  |  Issue: In Press  |  https://doi.org/10.31024/ajpp.2020.6.6.4
Conjugated nanoconstructs of Dacarbazine for the treatment of metastatic melanoma

Harish Kumar Chandrawanshi*, Neelima Chandrawanshi, Neelesh Chaubey

College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, SH-18, Bhopal-Indore Road, Sehore-466002, M.P., India

*Address for Corresponding Author

Harish Kumar Chandrawanshi,

College of Pharmacy, Sri Satya Sai University of Technology and Medical Sciences, SH-18, Bhopal-Indore Road, Sehore-466002, M.P., India

Abstract

Objective: The prime objective of the study is to develop a dacarbazine loaded formulation with higher drug loading, improved systemic half-life and safety profile which can improve the patient compliance. Material and Methods: The Dacarbazine nanoparticles were processed by modified nanoprecipitation method. The processed nanoparticles are further described for particle size and zeta potential. TEM images of the prepared Dacarbazine loaded PLGA nanoparticles shows that they are smooth, spherical, discrete and uniform. The in vitro release of Dacarbazine and other studies were performed. Results: A raise in the percentage of the polymer an increase of the particle size was observed. Greater value of zeta potential more stable nano suspension and lower value points out the instability. TEM images of the Dacarbazine loaded PLA nanoparticles shows that they are smooth, spherical, discrete and uniform. The increase in concentration of the polymer in the organic phase caused the increase in drug content of the nanoparticles. The percentage drug entrapment efficiency was dependent on the polymer ratio, stirring speed and stirring rpm, entrapment efficiency of the PLA nanoparticles were found to be increased up to drug: polymer ratio of 1:3. An early quick release suggests that some quantity of drug was restricted on the outward of nanoparticles. Conclusion: The prepared nanoparticles exhibited high encapsulation efficiency, high drug content and moreover particle size is in nano range, zeta potential determination shows that they are stable. In vitro release other studies provided sustained release of the drug and stable formulation.

Keywords: Dacarbazine, PLGA, PLA, nanoformulation, melanoma

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