Neeraj Kumar1*, Anita Singh2, D. K. Sharma3, Kamal Kishore4
1Associate Professor, Dr R M L Institute of Pharmacy, Kunwarpur Badagaon, Powayan, Shahjahanpur-242401, Uttar Pradesh, India.
2Professor, Department of Pharmacy, Kumaun University, Bhimtal, Nainital-263136, Uttarakhand, India.
3Professor, School of Pharmaceutical Sciences, Sanskriti University, Mathura-281401, Uttar Pradesh, India
4Profesor, Department of Pharmacy, M J P Rohilkhand University, Bareilly-243006, UP, India.
*Address for Corresponding author
Dr. R. M. L. Institute of Pharmacy, Kunwarpur Badagaon, Uttar Pradesh, India
Objective: Anaphalis triplinervis or Bhukiphul, used as wound healer by tribes of western Himalayan region. This claim of wound healing potential was validated by this study using excision and incision wound models in rats. Materials and methods: In this study total five parameters were considered like wound surface area, percentage wound contraction, tensile strength, epithelization time and wound index in 13 days study. Results: The plant showed more than 10 % increase in percentage wound contraction in excision wound and significant increase (44.9%) of tensile strength in incision wounds as compared to control. Period of epithelization was decreased (29.7%) significantly which indicate that healing become faster in extract treated rats then control. The wound index data also suggested that quality of healing increased very significantly as wound index decreased (76.8%) sharply in comparison to control. Conclusion: The results showed that Anaphalis triplinervis have significant (p<0.05 to p<0.01) wound healing potential in both excision and incision wounds when compared with control.
Keywords: Wound, healing, excision, incision, wound index