Research Articles

2019  |  Vol: 5(4)  |  Issue: 4 (July- August)  |  https://doi.org/10.31024/ajpp.2019.5.4.2
Evaluation of anticonvulsant activity of Majoon Najah in experimental animal model

Zeba Afrin1, Aisha Siddiqui2*, M. A. Jafri3, Divya Vohora4, M. Asif2

1Research Associate, Central Council for Research in Unani Medicine Headquarters, Janakpuri, New Delhi, India

2Assistant Professor, Department of Ilmul Advia, School of Unani Medical Education & Research, JamiaHamdard, New Delhi, India

3Professor, Department of Ilmul Advia, School of Unani Medical Education & Research, Jamia Hamdard, New Delhi, India

4Professor and Head, Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi

*Address for Correspondence:

Dr. Aisha Siddiqui

Department of Ilmul Advia, School of Unani Medical Education & Research, Jamia Hamdard, New Delhi, India

Abstract

Objective: To compare the anticonvulsant activity of Majoon Najah, its hydroalcoholc extract and granular form through Increased Current Electroshock Seizure (ICES) test in swiss albino mice. Methods: Majoon Najah, its hydroalcoholic extract and granular form were tested for anticonvulsant activity using ICES animal model. To evaluate the effect of test drugs on motor co-ordination, muscle co-ordination test by rotarod was carried out. Results: In ICES test Seizure Threshold Current (STC), duration of hindlimb extension (HLE) and percent protection were observed. It was found that MN (p<0.01), HEMN and GMN (p<0.001) significantly increased the seizure threshold current when compared with control. Although HEMN increased the STC more significantly than MN and GMN but intra-comparison between MN, HEMN and GMN showed no statistical significant variation in the activity. Conclusion: It can be concluded from the experiment performed that Majoon Najah possess significant anticonvulsant activity.

Keywords: Majoon Najah, anticonvulsant, ICES

Manuscript Management System
Submit Article Subscribe Most Popular Articles Join as Reviewer Email Alerts Open Access
Our Another Journal
Another Journal
Call for Paper in Special Issue on

Call for Paper in Special Issue on