Research Articles

2018  |  Vol: 4(2)  |  Issue: 4(March-April)  |  https://doi.org/10.31024/ajpp.2018.4.2.12
Synergistic effect of Lemon and Ginger juice for analgesic activity on Swiss albino mice

Sangita Bhandare1*, Kiran Kotade2

1Department of Pharmacology, P.R.E.S.’s. College Of Pharmacy (FOR WOMEN), Chincholi, Nashik, Maharashtra, India

2Department of Pharmacology, P.R.E.S.’s. College Of Pharmacy (FOR WOMEN), Chincholi, Nashik, Maharashtra, India

*Address for Corresponding Author

Sangita Bhandare

Assistant Professor

Department of Pharmacology,  P.R.E.S.’s. College Of Pharmacy (FOR WOMEN),

Chincholi, Nashik, Maharashtra, India

Abstract

Objective: The present study was carried out to investigate the  synergestic effect of  lemon and ginger juice for central and peripheral analgesic activity on  experimental animals  using Acetic acid induce writhing,  Hot plate and Tail immersion methods. Material and methods: The central analgesic activity was measured by Hot plate and Tail immersion methods in Swiss albino mice and peripheral analgesic activity was measured by acetic acid induced writhing in Swiss albino mice.  Aspirin was used as the standard drug in the dose of 100 mg/kg. The lemon juice and ginger juice was administered at 0.8 ml per animal. Phytochemical analysis showed the presence of flavonoids, alkaloids, glycosides, saponins, tannins, sterols, carbohydrates, and resins. Result: All the doses showed significant central and peripheral analgesic activity i.e (p<0.05), which is comparable to that of the control and standard drug aspirin. The test and standard drugs significantly (p<0.05) reduced the number of abdominal constriction and stretching of hind limb induce by the injection of acetic acid in a dose dependent manner. The Hot plate and Tail immersion test useful in the elucidating centrally mediated antinociceptive responses, which focused mainly on changes above the spinal cord level. All the test and standard drugs significantly (p<0.05) reduced the pain as compare to the control group. Conclusion: The results of pharmacological tests performed in the present studies suggest that the lemon and  ginger juice in combination gives Synergestic effect for analgesic activity.

Keywords: Lemon juice, Ginger juice, Analgesic

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