Research Articles

2018  |  Vol: 4(5)  |  Issue: 5 (September- October)  |
Study on cultivation of cyanobacteria and extraction of antimicrobial compounds against pathogenic bacteria

Gunaswetha Kuraganti ¹, Sujatha Edla²*

¹Research Scholar, Department of Microbiology, Kakatiya University, Warangal-506009, Telangana, India

²Assistant Professor, Department of Microbiology, Kakatiya University, Warangal 506009, Telangana, India

*Address for Corresponding Author

Edla Sujatha

Department of Microbiology, Kakatiya University, Warangal 506009, Telangana, India


Objective: Focusing on bioproducts, ongoing patterns in drug research have demonstrated that microalgae are promising organisms to outfit novel and more secure naturally vital compounds. Cyanobacteria are considered as potential source of antibiotic production. Materials and Methods: Twenty cyanobacterial strains from different habitats belonging to various genera were isolated cultured and tested for their antimicrobial activity. Among the isolates, percentage of incidence and frequency of Microcystis was more in Badrakali freshwater lake and Adilabad mavala lake. The biomass of cyanobacterial sp  were lyophilized and extracted with ethyl acetate and crude extracts were subjected to TLC purification twice and tested for antibacterial activity against two Gram+ve bacteria (Staphylococcus aureus, Micrococcus luteus) and four Gram-ve bacteria (Escherichia coli, Klebsiella pneumonia, Salmonella typhi, Salmonella paratyphi) by Agar well diffusion method. Results: Ten strains showed activity against at least two of the test organisms. Bioactivity was more by extract of ethyl acetate. Extracts of  Oscillatoria strains (MBKG02) were shown more antibacterial activity on E. coli (22mm)  and S. paratyphi (19mm)  where as Microcystis sp (MBKG16, MBKG08) shown more activity against S. paratyphi (20mm). Microcystis (MBKG 07) strain has shown more inhibitory effect on S. paratyphi (10mm). Conclusion: The results obtained in the present study clearly suggest that the production of antibacterial products from cyanobacterial sp could represent a viable and eco-friendly to reduce the use of synthetic drugs. The presence of antibacterial activity was independent of the strain origin.

Keywords: Cyanobacteria, thin layer chromatography, antibacterial activity

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