Review Articles

2018  |  Vol: 4(2)  |  Issue: 4(March-April)  |  https://doi.org/10.31024/ajpp.2018.4.2.7
Systematic Review of Eperisone for Low Back Pain

Rizaldy Taslim Pinzon*, Rosa De Lima Renita Sanyasi

Faculty of Medicine Duta Wacana Christian University, Yogyakarta

*Corresponding Author

Rizaldy Taslim Pinzon

Faculty of Medicine Duta Wacana Christian University, Yogyakarta

Abstract

Background: Low back pain (LBP) is the main cause of disability. Eperisone is a centrally acting muscle relaxants. It is often used to alleviate musculoskeletal pain including LBP. Objective: This systematic review aimed to identify the effectiveness of eperisone in LBP. Methods: Systematic research was conducted by using PubMed and Cochrane with following terms to search: “eperisone”, “low back pain and eperisone”, “low back pain and muscle relaxant’, “low back pain and antispasmodic”, “randomized controlled trial eperisone”, and “randomized controlled trial muscle relaxant”. The quality of randomized controlled trial (RCT) study is assessed by using the Jadad score by and the selected studies were reviewed by using PRISMA checklist as the guidance.Results: There were 1389 citations from PubMed and Cohcrane. After screening for title and abstract, irrelevant topic, availability of full text, duplication, the final result was 6 RCT. All studies have a great quality. Subjects in all study were patients with LBP. Eperisone in these study compared to eperisone with different dosage, tizanidine, thiocolchicoside, diazepam, or placebo. Thiacolchicoside was the most common comparison. Visual Analogue Scale (VAS) and Finger to Floor Distance (FFD) were the most common outcome measurement. Conclusion: Eperisone represents a good efficacy to treat LBP and has a better tolerability.

Keywords: systematic review, low back pain, eperisone, muscle relaxant

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