Reetesh Yadav, Varsha Kashaw*
SVN Institute of Pharmaceutical Sciences, Swami Vivakanand University, Sagar, Madhya Pradesh, India
*Address for Corresponding Author
Dr. (Mrs.) Varsha Kashaw
SVN Institute of Pharmaceutical Sciences,
Swami Vivekananda University, Sagar (M.P.) India
Objective: The objective of present paper to evaluate anti-inflammatory activity of Amoora rohituka and Soymida febrifuga belongs to family Meliaceae. The Meliaceae plants are known to be rich sources of limonoids. A number of limonoids have been isolated from several genera of Meliaceae and some of this exhibit anticancer, antimalarial, cytotoxic, antiprotozoal, antifeedant and many various activities. Materials and Methods: Anti-inflammatory effect of the alcoholic, hydro-alcoholic (40:60) and aqueous extracts of the Amoora rohituka and Soymida febrifuga stem barks were studied in albino rat using the carrageenan – induce rat paw oedema methods. The hydro-alcoholic extracts of both stem barks belongs to inhibit the carrageenan – induce rat paw oedema at dose of 100 mg/kg p. o. where the standard drug was Indomethacin at dose 10 m g/kg p. o. Results and Conclusion: The results indicated that the hydro-alcoholic extracts of Amoora rohituka and Soymida febrifuga stem barks produced significant (p<0.05) anti-inflammatory effect with Indomethacin as standard at dose 10mg/kg p. o.
Keywords: Anti-inflammatory, Amoora rohituka, Soymida febrifuga, Indomethacin