Research Articles

2018  |  Vol: 4(6)  |  Issue: 6 (November-December)  |  https://doi.org/10.31024/ajpp.2018.4.6.28
Evaluation of anti-inflammatory activity of alcoholic, hydroalcoholic and aqueous extract of Amoora Rohituka and Soymida Febrifuga in albino rats

Reetesh Yadav, Varsha Kashaw

SVN Institute of Pharmaceutical Sciences, Swami Vivakanand University, Sagar, Madhya Pradesh, India

*Address for Corresponding Author

Dr. (Mrs.) Varsha Kashaw

Professor

SVN Institute of Pharmaceutical Sciences,

Swami Vivekananda University, Sagar (M.P.) India

Abstract

Objective: The objective of present paper to evaluate anti-inflammatory activity of Amoora Rohituka and Soymida Febrifuga belongs to family Meliaceae. The Meliaceae plants are known to be rich sources of limonoids. A number of limonoids have been isolated from several genera of Meliaceae and some of this exhibit anticancer, antimalarial, cytotoxic, antiprotozoal, antifeedant and many various activities. Materials and Methods: Anti-inflammatory effect of the alcoholic, hydro-alcoholic (40:60) and aqueous extracts of the Amoorarohituka and Soymidafebrifuga stem barks were studied in albino rat using the carrageenan – induce rat paw oedema methods. The hydro-alcoholic extracts of both stem barks belongs to inhibit the carrageenan – induce rat paw oedema at dose of 100 mg/kg p. o. where the standard drug was Indomethacin at dose 10 m g/kg p. o. Results and Conclusion: The results indicated that the hydro-alcoholic extracts of Amoorarohituka and Soymidafebrifuga stem barks produced significant (p<0.05) anti-inflammatory effect with Indomethacin as standard at dose 10mg/kg p. o.

Keywords: Anti-inflammatory, Amoorarohituka, Soymidafebrifuga, Indomethacin

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