Lecturer in Pharmaceutics
Department of Pharmaceutical Education and Research,
Bhagat Phool Singh Mahila Vishwidylaya, South campus, Bhainswal Kalan,
Sonepat, Haryana, India.
In the Gastroretentive drug delivery system (GRDDS), the dosage form that after oral administration retained in the stomach and release the drug in a controlled and prolonged manner, so that the drug could be supplied continuously to its absorption sites in the upper gastrointestinal tract. In the gastric region, gastro retentive dosage form can remain for several hours and prolong the gastric residence time of drugs significantly. While, the bulk density in floating drug delivery system (FDDS) is more than the gastric fluids and therefore, they remain buoyant in the stomach for a long-time period without affecting gastric emptying rate. When the system is floating on the gastric fluid; the drug releases slowly. This results in an increased gastric residence time and a good control of the rise and fall in plasma drug concentration. For local action in the upper part of the small intestine i.e. treatment of peptic ulcer disease, longer residence time in the stomach could be advantageous. Moreover, drugs that are absorbed readily upon release in the GI tract, improved bioavailability is expected by slow release in the stomach. By the simultaneous administration of pharmacological agents, the controlled gastric retention of solid dosage forms may be achieved that delay gastric emptying or it may be achieved by the mechanisms of sedimentation, flotation, muco-adhesion, expansion, modified shape systems. The main purpose of this paper is to review the concept of gastroretentive drug delivery systems with the recent literature and current technology used in the development of this system.
Keywords: Gastroretentive Floating drug delivery system, Gastric Residence Time