Review Articles

2020  |  Vol: 6(6)  |  Issue: In Press  |  https://doi.org/10.31024/ajpp.2020.6.6.1
Novel approach to improve bioavailability and factors affecting to stability of nanoformulaiton

Vikrant K. Nikam1*, Ankita Ugale1, Jyoti Khapare2

1Amrutvahini College of Pharmacy, Sangamner 422 608, (MS) India

2Dr. Naikwadi college of Pharmacy, Jamgaon Sinnar 422 113, (MS) India

*Address for Corresponding Author

Vikrant K. Nikam

Amrutvahini College of Pharmacy, Sangamner (M.S.) 422608, India


Abstract

In 20th century 1970s and 80s when the first thorough fundamental studies in the united states and japan researchers used the term ultrafine particles. However during the 1990s before the national nanotechnology initiative was launched in the United States the term nanoformulation had become more common. Drug delivery system is defined by national institute of health in USA as, “Formulation of a device that enables the introduction of therapeutic substances in to the body and improves efficiency and safety by controlling the rate, time and place of release of drug in the body. Conventional Drug delivery system has many drawbacks including poor bioavailability, side effects, low drug loading capacity, plasma fluctuation of the drug levels, low therapeutic effectiveness, and lack of target delivery. For example, in cancer treatment the conventional drug delivery to the tumor cells can affect normal tissues causing nephrotoxicity, neurotoxicity, cardio toxicity. These drawbacks have motivated on scientists to investigate more about new Drug delivery system. The chemical and physical properties of nanoparticles make then efficient Drug delivery system that have the potential to improve the bioavailability, drug carrying capacity, stability for the drugs within the body. Novel drug delivery system is a combination of advance technique and new dosage form which are better than conventional dosage form. Basic modes of novel drug delivery system are Targeted drug delivery system, controlled drug delivery system which is used in pharmaceutical science. The present reviews gives information regarding various novel techniques used for improving safety and efficacy of phytomedicines and application of novel formulation.

Keyword: Novel drug delivery nanoformulation, stability, impurity

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