B. Sudheer Chowdary*, M. Sathish Kumar, M. Vamsi Krishna, K. Vikram Kumar, M. Jesu Mercy, V. Mohan Aditya, P. Tejasri
Department of Pharmacology, Bapatla College of Pharmacy, Bapatla, Guntur (Dt),
Andhra Pradesh, India
*Address of the Corresponding Author:
B. Sudheer Chowdary
Bapatla College of Pharmacy, Bapatla - 522101, Guntur (Dt), Andhra Pradesh, India
Background: Wounds are inescapable events of life which are due to physical, chemical and microbial infections. Medicinal plants came into prominence having good wound healing activity with low adverse drug reactions than the synthetic drugs. Objective: The present study was designed to evaluate the wound healing activity of Euphorbia antiquorum ethanol stem extract formulation on the wistar rats by using excision wound model. Materials and Methods: Animals are divided into three groups containing six animals each. Excision wound was made on the back of rats near the neck region about 2mm diameter. The Euphorbia antiquorum ethanol extracts were formulated into ointment by using hydrophilic base containing 2.5 and 5 percentage strength. The formulations were applied on the wounds twice a day and wound healing was observed on the 5, 10, 15, 20th days. Wound contraction period, percentage of inhibition and bio chemical parameters were observed. Results: The wound contraction for the Euphorbia antiquorum 2.5% ointment was 45.76% ±3.07 to 98.05% ±0.24 and 5 % ointment was 72.45% ±3.43 to 99.13% ± 0.25. Significant wound contraction was observed in 5% strength containing formulation when compared with control and standard. Conclusion: Thus from the present study Euphorbia antiquorum ethanol formulation (5% ointment) showed significant wound healing activity compared with standard and control groups.
Keywords: Wound healing, Euphorbia antiquorum, excision wound model, ethanol extract