Research Articles

2019  |  Vol: 5(5)  |  Issue: 5(September- October)  |  https://doi.org/10.31024/ajpp.2019.5.5.2
Investigative studies on pharmacological potential of HDAC inhibitor on heavy metal induced Neurodegeneration

Dharmendra Chaudhary, Anant Srivastava*, Rishabh Singh

Hygia Institute of Pharmaceutical Education and Research, Faizullaganj, Prabandh Nagar, Lucknow-226013 India

*Correspondence to Author:

Anant Srivastava

Assistant Professor,

Department of Pharmacology,

Hygia Institute of Pharmaceutical Education and Research, Faizullaganj, Prabandh Nagar, Lucknow-226013 India

Abstract

Objective: To study the neuroprotective effect of Sodium butyrate against CdCl2 induced dementia in rats. Materials and methods: The neuroprotective activity of HDAC inhibitor, sodium butyratewas evaluated against CdCl2 induced dementia in adult male Albino Wistar rats. A number of behavioral (Elevated plus maze and Morris water maze; Assessment of learning and memory) and biochemical (brain/ serum levels of nitrite/nitrate, Aortic Superoxide Anion, calcium, GSH, TBARS, CAT, AChE) parameters were assessed. Results and discussion: In comparison to the disease control, administration of sodium butyrate (HDACi) significantly attenuates the CdCl2induced behavioral alternations like learning and memory impairment; andincreased the brain/serum levels of acetylcholinesterase (AChE), catalase (CAT), reduced glutathione (GSH), thiobarbituric acid reactive species (TBARS), brain calcium levels, aortic superoxide anionand nitrite/nitrate levels. Conclusion: The results clearly indicate that oxidative stress and lipid peroxidation are the primary mechanisms involved in the pathogenesis of CdCl2 induced dementia.The research aims to identify and implement the therapeutic potential of HDACi in the treatment of dementia. It is concluded that a target based drug research against pathogenic mechanisms like oxidative stress and lipidperoxidation may help to alleviate ailments associated with neurodegeneration.

Keywords: Neuroprotective, Dementia, Sodium butyrate, catalase, vascular dementia

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