Research Articles

2018  |  Vol: 4(5)  |  Issue: 5 (September- October)  |  https://doi.org/10.31024/ajpp.2018.4.5.8
Fabrication and characterization of pantoprazole sodium Ora-Solv tablets using different superdisintegrants

Sai Charitha CH.*, Swathi N., Chandi Rani P., Nikitha M., Meghana N., Rama Rao N.

Department of Pharmaceutics,

Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522043, Andhra Pradesh, India

*Address for Corresponding Author

Sai Charitha CH.

Department of Pharmaceutics,

Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur- 522043, Andhra Pradesh, India

Abstract

Objective: In the present investigation, an attempt has been made to formulate Ora – Solv tablets of pantoprazole sodium using two different superdisintegrants like crosspovidone and primogel by direct compression method. Materials and methods: ORA-SOLV tablets of pantoprazole were prepared by direct compression method. In the present investigation, each superdisintegrant was used in three concentrations (2.5, 5 and 10%). Weighed quantities of Pantoprazole sodium along with appropriate concentrations of superdisintegrants i.e crosspovidone and primogel, mannitol, microcrystalline cellulose, saccharin sodium were weighed and mixed in geometric progression in a dry and clean mortar. Superdisintegrants act by decreasing the disintegration time which leads to enhanced dissolution rate. Evaluation of formulations showed that all the preparations were within the sandard limits and the disintegration time for formulations ranges from 12.10 sec to 27 sec. Results and conclusion: It was observed that with the increase in the concentration of superdisintegrant the disintegration time decreases and among all formulation, tablets containing crosspovidone shows less disintegration time due to more hydrophilicity. From the obtained results, formulation F3 containing 10% w/w concentration of crosspovidone was considered to be the optimized formulation which releases up to 99.78% of the drug in 15 minutes. The OST’s have potential advantages over conventional marketed tablets with their better patient compliance, both in geriatrics and pediatrics, ease of administration and bio-availability.

Keywords: Ora – Solv tablets, Pantoprazole, Crosspovidone, Primogel, direct compression

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