Research Articles

2017  |  Vol: 3(6)  |  Issue: 6 (November-December)
Formulation and evaluation of colon specific drug delivery of Eterocoxib by using Okra Gum

Chindam Suresh*, Kondapuram Parameshwar, Kosika Sandeep

Department of Pharmaceutics, School of Pharmacy, Gurunanak Institute of Technical Campus, Hyderabad, Telangana, India.

*Address for corresponding Author

Chindam Suresh

Assistant Professor

School of Pharmacy, Guru Nanak Institutions Technical Campus, Hyderabad, Telangana, India


Objective: Design and  development  of  okra  gum  based  colon  specific  tablet formulations for chronotherapeutic delivery  of drugs, Eterocoxib  for  the  treatment  of  diseases. Materials and methods: The gum extracted from thoroughly washed, sliced and crushed fruits with a laboratory blender. After extraction the precipitate of the gum  were  dried  in  hot  air  oven  for  about  20min  at  50C  and  then precipitates were kept in a dessicator for further drying Etoricoxib, HPMC, E.C other formulation excipients. The in vitro dissolution test has been performed in 0.1 N HCl for first two hours and the rest in 6.8 pH phosphate buffer using USP apparatus type II (paddle), at 50 rpm for six hours. The  spectrum  was  measured  in  the  solid  state  as  Potassium  bromide dispersion..The Press coated tablets were prepared by varying polymer (HPMC): polymer (E.C) ratio i.e., 4:0, 3:1, 2:2, 1:3, 3:1 and 0:4. Results and conclusion: The drug release from the  dosage forms was started after 4hrs lag time.The Press coated tablets obtained by 3:1 ratio (P2F9) shows good lag time, more % drug released immediately  after lag time  in comparision with those prepared by 4:0, 2:2, 3:1, 0:4  hence P2F9. It has been concluded from the above investigation that Press coated dosage form of Etoricoxib could delay the release up to 4hrs and further exhibited immediate release of the drug and shows 20 hr action. The results obtained in this research work clearly indicated a promising potential of colon specific drug delivery of eterocoxib by using okra gum containing HPMC, HPMS EC, as a rate controlling polymer for the effective treatment of rheumatoid patients.

Keywords: HPMC, HPMC, E.C, Okra Gum, colon specific drug delivery

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