Research Articles

2020  |  Vol: 6(4)  |  Issue: 4 (July- August)  |  https://doi.org/10.31024/ajpp.2020.6.4.6
Study of steroid induced hyperglycemia against traditional hypoglycemic plant extracts in rat model

Rupsana Perven Borsha1*, Rakibul Islam1, Md. Bazlar Rashid1, Fahima Binthe Aziz1, Md. Nazrul Islam2, Mahmudul Hasan1

1Department of Physiology and Pharmacology, Hajee Mohammad Danesh Science and Technology University, Dinajpur-5200, Bangladesh

2Department of Pathology and Parasitology, Hajee Mohammad Danesh Science and Technology University, Dinajpur-5200, Bangladesh

*Address for Corresponding Author

Rupsana Perven Borsha

Department of Physiology and Pharmacology, Hajee Mohammad Danesh Science and Technology University, Dinajpur-5200, Bangladesh

 

Abstract

Background and Objective: Now a days corticosteroid drugs are used as a treatment and longtime use of the drug elevates the blood glucose level results in steroid hyperglycemia. Moreover, treatment of study was undertaken to examine the effect of Gynura procumbens plant on steroid induced hyperglycemia in rats. Therefore, present of hyperglycemia by synthetic drug may develop health risk along with adverse effects. Material and methods: Fifteen Long evan male rats were assigned into three different groups and each group had 5 rats for 21 days. . Group T0 served as negative control, Group T1 served as positive control was treated with dexamethasone intramuscularly with 5 mg/kg body wt. Group T2 served as treatment group injected with dexamethasone with 5 mg/kg body wt. intramuscularly and treated with Gynura procumbens ethanolic extract with 150 mg/kg body wt. orally for 21 consecutive days. After that extract effect was observed on blood glucose, lipid profile, HbA1c and insulin level by biochemistry analyzer and live body weights were weighed and recorded by digital balance. Histopathology of rat pancreases was also observed for all of groups. Results and conclusion: Blood glucose level was significantly increased in the treatment group than the negative control group. The HbA1c and lipid profile values were greatly enhanced while the final body weight of different groups met a significant reduction from the initial body weight. Insulin level showed negligible changes which was statistically significant. Histopathological changes indicate to neoplastic growth over the Langerhans cells. At the end this study shows that chronic steroid therapy induces hyperglycemia that is irresponsive to Gynura procumbens treatment.

Keywords:  Gynura procumbens, dexamethasone, hyperglycemia, langerhans cells, steroid

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