Research Articles

2018  |  Vol: 4(5)  |  Issue: 5 (September- October)  |  https://doi.org/10.31024/ajpp.2018.4.5.18
Formulation, development and characterization of transdermal drug delivery system for antidiabetic drug

Prashant Narayan Solanke *, Abdul Wahid Ambekar,   Satyam Chemate

Department of Pharmaceutics, Dr. Vithalrao Vikhe Patil Foundation’s College of Pharmacy, Vilad Ghat; P.O M.I.D.C, Ahmednagar – 414111 (M.S), India

*Address for Corresponding Author

Prashant Narayan Solanke

Department of Pharmaceutics, Dr. Vithalrao Vikhe Patil Foundation’s

College of Pharmacy, Vilad Ghat, P.O M.I.D.C, Ahmednagar 414111 (M.S), India.

Abstract

Background: The Transdermal Drug Delivery System is utilized for delivery of the drug through the intact skin into a systemic circulation. It is an alternative to oral drug delivery system and hypodermic injection. Saxagliptin belongs to the category of insulin-dependent antidiabetic drug which is used in the treatment of type 2 diabetes. Objective: The main aim of this research work is to formulate transdermal patch of Saxagliptin using a hydrophilic polymer which is intended to increase the bioavailability by penetrating poorly water-soluble drug through the surface of the skin and also making possible to avoid hepatic first pass metabolism. Materials and Methods: The present study was carried out to develop saxagliptin transdermal patch by using requisites ratio of a different polymer such as HPMC & PVP, along with Methanol, Dibutyl Phthalate and DMSO are used as a solvent, plasticizer and penetration enhancer respectively. Saxagliptin transdermal patch was prepared using solvent evaporation method. Results: The prepared transdermal films were evaluated for following parameters like thickness, weight variation, folding endurance, surface pH, tensile strength, percent flatness and drug content. In vitro drug permeation was determined by using Franz diffusion cell in phosphate buffer (pH 7.4). All the evaluation was done for six formulations F1 to F6. It was found that formulation F6 showed the best compatibility on the basis of the entire all evaluations test was performed. Conclusion: The obtained results conclude that the formulations can be promising therapeutic systems for the transdermal delivery of Saxagliptin to avoid the problem of the parenteral and oral route.

Keywords: Transdermal drug delivery system, patch, Saxagliptin, diabetes

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