Research Articles

2019  |  Vol: 5(5)  |  Issue: 5(September- October)  |  https://doi.org/10.31024/ajpp.2019.5.5.25
Formulation, characterization and biological evaluation of polyherbal tablet for antidiabetic potential in Streptozotocin induced diabetes in rats

Prashant Soni, Alok Pal Jain* 

Department of Pharmacology,  

RKDF College of Pharmacy, Sarvepalli Radha Krishnan University, Bhopal (M.P.) India

*Address for Corresponding Author

Dr. Alok Pal Jain

Department of Pharmacology,  

RKDF College of Pharmacy, Sarvepalli Radhakrishnan University, Bhopal (M.P.) India

Abstract

Objective: Present work was aimed to evaluate polyherbal tablet containing methanol extracts of Carissa carandus, Ocimum sanctum, Moringa oleifrea, Manilkara zapota. Material and methods: The dried plant extracts of all proposed plants were mixed with different excipient using wet granulation method to prepare tablets using compressing machine. Prepared herbal formulation was tested for in vivo studies for antidiabetic activity by using Streptozotocin induced diabetes model Effect of formulation were assessed by measurement of biochemical parameters and histological observations. Results: Preformulation study of the granules showed that all the evaluated parameters were within the acceptable limit. Prepared polyherbal tablet was selected that showed acceptable data of all characterization parameters. After treatment with formulation, STZ induced diabetic animals showed significant reduction in body weight, blood glucose level, and lipid profile when compared to the control animals. The serum total cholesterol, and Triglyceride level were significantly (P<0.01) decreases and restore near to the normal level. Polyherbal formulation treated animals reversed the effect of STZ on the renal antioxidant level. This may be due to the antioxidant mechanism of the individual herbs present in the polyherbal formulation. Conclusion Observation of the present study was confirmed that prepared formulation was safe, and effective for antidiabetic activity. It was confirmed that prepared formulation was able to restore lipid profile, blood glucose level and antioxidants level to the nearly of normal. These positive effects may attribute to the presence of various flavonoid constituents present in methanol extracts of all plants. Additionally this formulation also showed antioxidant effect that may another possible mechanism for antidiabetic effect of formulation.

Keywords: Carissa carandus, Ocimum sanctum, Moringa oleifrea, Manilkara zapota, ployherbal tablets, antidiabetic, Streptozotocin

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