Research Articles

2018  |  Vol: 4(5)  |  Issue: 5 (September- October)  |  https://doi.org/10.31024/ajpp.2018.4.5.19
Formulation development and evaluation of floating wax microspheres of Tizanidine hydrochloride

Punam Devidas Bairagi1*, Sheetal Bhaskar Gondkar1, Ravindranath Bhanudas Saudagar2

1Department of Pharmaceutics, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik,    Maharashtra – 422 213 India

2Department of Pharmaceutical Chemistry, R.G. Sapkal College of Pharmacy, Anjaneri, Nasik, Maharashtra – 422 213 India

*Address for Correspondence,

Punam Devidas Bairagi

Department of Pharmaceutics,

R. G. Sapkal College of Pharmacy, Anjaneri, Nasik, Maharashtra – 422 213 India

Abstract

Objective: The purpose of this study was to formulate and evaluate the floating wax beads by the ionotropic gelation method. Materials and methods: The wax in the pectin- oil emulsion was hot melted, homogenized and extruded into calcium chloride solution i.e. by ionotropic gelation method. The formulated microspheres were allowed to dry for 24 hrs. Further the formulated microspheres were evaluated for the parameters of micromeritic properties, floating lag time, floating time, surface characterization, in-vitro drug release etc.  Results: The effect of different amount of the wax and oil on the floating time and drug release was studied. The drug loaded microspheres were found to be float on the 0.1N hydrochloric acid solution. Addition of the wax into the microspheres affected the drug release. Conclusion: The results suggest that the increase in the concentration of the wax had significantly retarded the drug release and the wax microspheres could be used as the potential drug carrier for the sustained drug delivery system.

Keywords: Wax, microspheres, floating, pectin, drug carrier, sustained drug delivery

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