Research Articles

2019  |  Vol: 5(4)  |  Issue: 4 (July- August)  |  https://doi.org/10.31024/ajpp.2019.5.4.11
Hepatoprotective activity of the ethanolic extracts of Dipterocarpus turbinatus leaves in Paracetamol induced hepatotoxicity in rats

Diptanu Biswas1,2*, G. Nirmala2, P. Anjaneyulu2, B. Praveen Kumar2, K. Swathi2Suresh Kumar S. V.2

1Department of Pharmacognosy, Eminent College of Pharmaceutical Technology, Barasat, Kolkata-700126 India

2Department of Pharmacognosy, Creative Educational Society’s College of Pharmacy, NH-7, Chinnatekur, Kurnool, Andhra Pradesh-518218 India

*Address for corresponding Author

Dr. Diptanu Biswas

Assistant Professor

Department of Pharmacognosy

Eminent College of Pharmaceutical Technology, Babaria, Jagnnathpur, Barasat, Kolkata 700126, India

Abstract

Objective: Dipterocarpus turbinatus is a large woody plant widely grown in Northeastern state, Tripura. Ethanol extract of D. turbinatus leaves was evaluated for its antioxidant and hepatoprotective activity. Materials and Methods: The preliminary phytochemical study was carried out to find out the presence of various phytoconstituents in different extracts obtained by cold maceration. Antioxidant activity was done by Nitric oxide scavenging and DPPH* scavenging. Paracetamol (3gm/kg) was used to induce hepatotoxicity in rats and 200mg/kg & 400mg/kg of ethanol extract of leaves of D. turbinatus (EEDT) was used for the study, while silymarin (50mg/kg) was used as a standard. Blood was collected by retro-orbital puncture and various biochemical parameters were determined by photometric analysis. Results: Ethanolic extract showed different bioactive constituents like flavonoid, phenolic, alkaloid, tannin. Plant extract was exhibited antioxidant properties. Tested extracts showed a significant reduction in the elevated level of various biochemical parameters like SGOT, SGPT, ALP, total bilirubin & increase the level of protein level with the dose-dependent manner. Histopathological studies of the liver of the tested animal showed there is an improvement in the architecture of the hepatic cell with plant extract treatments. Conclusion: The results suggest that ethanolic extract of D.turbinatus leaves in different dose shows significant hepatoprotective activity against paracetamol-induced hepatotoxicity in rats.

Keywords: Antioxidant, Dipterocarpus turbinatus, hepatotprotective, Paracetamol

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