Ravikant Y. Patil*1, H. N. More2
1D.S.T.S. Mandal’s college of Pharmacy, Solapur, Maharashtra.
2Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra.
Ravikant Y Patil
Professor and Principal,
D.S.T.S. Mandal’s College of Pharmacy, Jule Solapur-1, Vijapur road,
Solapur, 413004, M.S. India.
Background: Antioxidants protect cells from damage by inhibiting oxidation that produces free radicals that damage the DNA that leads to cancer. Objective: The aim of the current study was to determine the role of antioxidants in the cancer patients of Solapur, Maharashtra, India. Materials and methods: Various parameters in the present study were Serum nitric oxide, total lipid peroxide and Total Antioxidants. Enzymatic antioxidants were studied by the estimation of erythrocytic Superoxide Dismutase and Glutathione Peroxidase. Similarly, the levels of non-enzymatic antioxidants such as vitamin E and vitamin C were also estimated. These biochemical parameters were compared within the groups of Cancer patients and normal healthy control subjects. Results: The investigation shows that the factors responsible for increase in the oxidative stress are elevated in the cancer patients compared to that of control. These values were decreased upon administration of the antioxidant supplement. The serum levels of enzymatic and non enzymatic antioxidants were decreased in the cancer patients. Conclusion: Antioxidant supplement leads to replenish their levels. Thus antioxidant is involved in decreasing the oxidative stress and further damage.
Keywords: Antioxidants, Cancer, Free radicals, Oxidative stress, Reactive oxygen species.