Research Articles

2020  |  Vol: 6(3)  |  Issue: 3 (May- June)  |  https://doi.org/10.31024/ajpp.2020.6.3.9
Comparative evaluation of Nardostachys jatamansi and Mucuna pruriens as neuroprotective in Parkinson's disease

Mahendra A. Giri1*, Rasika D. Bhalke2, K. Vanitha Prakash3, Sanjay B. Kasture4

1Department of Pharmacology, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, India 423603

2Department of Pharmacognosy, Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, India 423603

3Department of Pharmaceutics, Shri Sai Jyoti College of pharmacy, Vattinagula Pally, Gandhipeth, Hydrabad-500075 Telangana, India

4Department of Pharmacology, Pinnacle Biomedical Research Institute, Bhopal, Madhya Pradesh, India

*Address for Corresponding author

Mahendra A. Giri

Department of Pharmacology,

Sanjivani College of Pharmaceutical Education and Research, Kopargaon, Maharashtra, India 423603

 

Abstract

Objective: In the present study, comparative antioxidant and antiparkinsonian effect of hydroalcoholic extract of Nardostachys jatamansi (HENJ) and Mucuna pruriens (HEMP) was studied. Materials and methods:  The antiparkinsonian activity was evaluated by using haloperidol induced catalepsy, reserpine induced hypolocomotion, tacrine induced vacuous chewing movements, orofacial brusts and tongue protrusion. Antioxidant activity was assessed by using DPPH radical scavenging assay and H2O2 scavenging assay. The results were analyzed by repeated measure ANOVA followed by Dunnett's test. Results: Mixture 30 and 100 mg/kg shows extremely significant improvement in haloperidol induced catalepsy, reserpine induced hypolocomotion and tacrine induced vacuous chewing movements, orofacial burst and tongue protrusion as compare with HENJ and HEMP shows significant improvements in dose dependent manner. In DPPH and H2O2 scavenging assay, both the extracts exhibited free radical scavenging activity. In DPPH assay the IC50 value of ascorbic acid, HENJ, HEMP and Mixture (1:1) was 18.15, 211.54, 114.85 and 109.12μg/ml respectively whereas in H2O2 assay it was 28.58, 146.58, 98.18 and 179.47μg/ml respectively. Conclusion: Hydroalcoholic extracts has showed almost significant protections but mixture of extracts has shown extremely significant protection against haloperidol induced catalepsy, tacrine induced vacuous chewing movements, orofacial burst, tongue protrusion and reserpine induced hypolocomotion.

Keywords: Antiparkinsons, antioxidant, Nardostachys jatamansi, Mucuna pruriens, haloperidol, tacrine, reserpine

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