Sweta Garg1*, Ashish Garg1, Ajay Shukla2, Suresh Kumar Dev2, Manish Kumar2
1Department of Chemistry and Pharmacy, Rani Durgavati University, Jabalpur-482001, MP, India.
2Department of Pharmaceutical Sciences, Mohanlal Sukhadia University Udaipur 313001 Rajasthan India
Assistant Professor, Department of Chemistry and Pharmacy
Rani Durgavati University, Jabalpur, (M.P.), 482001, India
Background: Wound healing is an intricate process that requires complex coordination between many cell types and an appropriate extracellular microenvironment. Chronic wounds often suffer from high protease activity, persistent infection, excess inflammation, and hypoxia. While there has been intense investigation to find new methods to improve cutaneous wound care, the management of chronic wounds, burns, and skin wound infection remain challenging clinical problems. Objectives: In this review paper we discuss recent advances in the development of biomaterials and nanocarrier therapeutics to enhance wound healing. In particular, this review focuses on the novel cutaneous wound treatments that have undergone significant preclinical development or are currently used in clinical practice. Conclusion: Ideally, advanced wound dressings can provide enhanced healing and bridge the gaps in the healing processes that prevent chronic wounds from healing. These nanotechnologies have great potential for improving out-comes in patients with poorly healing wounds but face significant barriers in addressing the heterogeneity and clinical complexity of chronic or severe wounds. Active wound dressings aim to enhance the natural healing process and work to counter many aspect that plague poorly healing wounds, including excessive inflammation, ischemia, scarring, and wound infection.
Keywords: Nanotherapeutics, biomaterials, nanoparticles, wound care, wound healing, microsphere, liposome, hydrogel