Research Articles

2021  |  Vol: 7(1)  |  Issue: 1(January-February)  |  https://doi.org/10.31024/ajpp.2021.7.1.2
Evaluation of effervescent floating bed of Lafutidine in treatment of hyperacidity condition: Statistical design and in-vitro studies

Pankaj Vaghasiya, Dhara Amitkumar Chavda*, Malaykumar Bhavanbhai Chotaliya, Anjali Pratik Sangani, Reena Govindbhai Korat, Mina Jaysukhbhai Sinhar

Shree H. N. Shukla Institute of Pharmaceutical Education & Research, Rajkot

B/H lalpari lake, Marketing Yard (Bhichri), Rajkot-360005 Gujarat (India)

*Address for Corresponding Author

Dr. Dhara Amitkumar Chavda

Head, Shree H. N. Shukla Institute of Pharmaceutical Education and Research-Rajkot

B/H lalpari lake, Marketing Yard (Bhichri), Rajkot-360005, Gujarat, India

 

Abstract

Objective: The current study involves the development of oral effervescent floating bed of Lafutidine and the optimization of their in-vitro drug release. Materials and methods: A 32 Full factorial design was employed to systematically optimize the drug delivery containing two polymers. Inotropic gelation method was utilized to prepare floating beads. The proportions of Sodium Alginate and Sodium Bicarbonate were varied to be fitted in 32 full factorial design. Percent entrapment efficiency (M), drug release at 24h were taken as responses. Response surface plots were drawn and the optimum formulation was selected by desirability function. Results: In-vitro drug release study was carried out using simulated gastric fluid (SGF) pH 1.2. The experimental values of M, % Entrapment efficiency and % drug release at 1hr for check point batch were found to be 84.33%, and 22.05% respectively. The release profile indicated anomalous (non-Fickian) transport mechanism. Conclusion: The developed formulation was stable and provided sustained release of the drug over a period 12 hr. The optimized batch was passed stability test. It is concluded that the method attempted to formulate effervescent floating beads of lafutidine being simple and acceptable.

Keywords: 32 full factorial design, floating bed, ionotropic gelation, sweling index, entrapment efficiency

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