Neelima Salvi *, Gajendra Pratap Choudhary
Department of Pharmaceutics, School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, M.P. India-452001
*Address for Corresponding Author
Mrs. Neelima S. Naneriya
School of Pharmacy
Devi Ahilya Vishwavidhyalaya, Indore, (MP) India-452001
Objective: Formulation and characterization of solid lipid nanoparticles containing murrayanol for better management of diabetes mellitus. Material and methods: Successive solvent extraction of crude drug of Murraya koenigii plant was done. Active constituent of leaves that is murrayanol was isolated and identified through HPLC and FTIR. SLN was selected as carrier system and formulated by solvent diffusion method. Characterization and performance evaluation of particulate system loaded with herbal plant extract of the Murraya koenigii leaves was done. TEM, In-vitro drug release profile, entrapment efficiency and particle size was determined. Results: Solid lipid nanoparticles have enormous effect in loading high amount or loading dose concentration in body and also maintain the same over prolonged period of time. SLN was formulated and characterized for the particle size, shape and its distribution, percentage drug entrapment and In-vitro drug release profile along with the stability studies. In-vivo bio distribution studies on animals suggested the accumulation of formulations in the different organs. Solid lipid nanoparticles also show good stability as compared to other novel carrier systems. Conclusion: Prolonged release of natural drug from carrier system, decrease the dosing frequency and also decrease the dose size. Better results than marketed synthetic anti-diabetic drugs.
Keywords: Particulate system, plant extract, Murraya koenigii, diabetes mellitus